Analysis of the Efficacy of Topical Aqueous Creams Containing

Abstract

In context, wounds are a kind of health problem that may have serious monetary and social consequences for the person who sustains them and their loved ones. Azadirachtaindica leaf aqueous extract (AEAIL) has been shown to have wound healing capability. The AEAIL may be more useful as a wound therapy if it were developed into a topical aqueous cream. Objectives: Using hydroxyproline (HXP) as a biochemical marker, the purpose of this work was to manufacture aqueous topical creams containing different concentrations of AEAIL as bioactive components, and then to assess their stability and wound healing activity in male Wistar rats. Using DMSO, cholesterol, and distilled water as controls, we tested the wound healing capabilities of creams containing 1.0, 1.5, 2.0, and 3.0% w/w AEAIL on male Wistar rats over the course of 14 days. The animals treated with the cream containing 1.5% w/w of AEAIL had the greatest tissue HXP level (p > 0.05), and all batches of cream were stable in terms of color, pH, viscosity, etc. Animals given DMSO, cholesterol, or distilled water had decreased tissue HXP levels compared to those given test creams (p 0.05). Their HXP levels were somewhat lower than those of the control creams, but the difference was statistically significant (p 0.05). The wound-healing properties of an aqueous cream containing an extract of Azadirachtaindica leaves were shown to be stable. As a result, this novel formulation may be employed to heal wounds to the human body.