Analysis of the Efficacy of Topical Aqueous Creams ContaininG

Abstract

In context, wounds are a kind of health problem that may have serious monetary and social consequences for the person
who sustains them and their loved ones. Azadirachtaindica leaf aqueous extract (AEAIL) has been shown to have wound
healing capability. The AEAIL may be more useful as a wound therapy if it were developed into a topical aqueous cream.
Objectives: Using hydroxyproline (HXP) as a biochemical marker, the purpose of this work was to manufacture aqueous
topical creams containing different concentrations of AEAIL as bioactive components, and then to assess their stability and
wound healing activity in male Wistar rats. Using DMSO, cholesterol, and distilled water as controls, we tested the wound
healing capabilities of creams containing 1.0, 1.5, 2.0, and 3.0% w/w AEAIL on male Wistar rats over the course of 14
days. The animals treated with the cream containing 1.5% w/w of AEAIL had the greatest tissue HXP level (p > 0.05), and
all batches of cream were stable in terms of color, pH, viscosity, etc. Animals given DMSO, cholesterol, or distilled water
had decreased tissue HXP levels compared to those given test creams (p 0.05). Their HXP levels were somewhat lower
than those of the control creams, but the difference was statistically significant (p 0.05). The wound-healing properties of
an aqueous cream containing an extract of Azadirachtaindica leaves were shown to be stable. As a result, this novel
formulation may be employed to heal wounds to the human body.