Phyllanthusniruri Linn.aqueous extract inhibits 2, 4- dinitrophenylhydrazine-induced anemia in rats.

Abstract

Jaundice, asthma, hepatitis, the flu, dropsy, diabetes, malaria, hemorrhages, diarrhea, and anemia are just some of the many
conditions historically treated using the annual herb Phyllanthusniruri throughout Asia and Africa.The purpose of this
research is to determine whether P. niruri has any antianemic properties by analyzing its haemotological and biochemical
characteristics in Wister rats with 2,4- dinitrophenylhydrazine-induced haemolytic anemia. This investigation uses
haemotological and biochemical parameters and body weight to assess the plant extract's antianaemic activity in Wister
rats with 2,4-dinitrophenylhydrazine-induced haemolytic anemia. Folic acid served as a positive control, and three
different dosages of plant extract (250, 500, and 1000 mg/ kg b.wt) were given to the test subjects. PCV, Hb, RBC, WBC,
MCV, MCH, and Reticulocyte count were among the haematological markers tested. Total and unconjugated bilirubin and
oxidative stress indicators (malonyl-CoA dehydrogenase, catalase, and superoxide dismutase) were also measured.