Through the PI3K/AKT and ERK pathways, NETO2 stimulates proliferation and metastasis, which advances the course of esophageal cancer.

Abstract

About 90% of esophageal cancer cases are esophageal squamous cell carcinomas (ESCC), which are

aggressive, deadly cancers with very poor prognoses. Genes that code for the proteins neuropilin and tolloid

like 2 (NETO2) have been linked to a number of human malignancies. However, not much is known

regarding the clinical importance of the phenotypic manifestation in the course of ESCC. According to our

research, the clinical stage of the tumor and the presence of lymph node metastases were related to NETO2

expression in ESCC patients.